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First purchase acticin 30gm mastercard stop acne, 1©X21©Y2 indicates to first find the sum of the Xs and the sum of the Ys and then multiply the two sums together acticin 30 gm without prescription acne under beard. Finally quality 30gm acticin acne tretinoin cream 005, D stands for the numerical difference between the X and Y scores in a pair cheap 30gm acticin overnight delivery acne 5 days before period, which you find by subtracting one from the other. Recall that a relationship is present when, as the X scores increase, the corresponding Y scores change in a consistent fashion. Whenever we find a relationship, we then want to know its characteristics: What pattern is formed, how consistently do the scores change together, and what direction do the scores change? The best—and easiest—way to answer these questions is to compute a correlation coefficient. The correlation coefficient is the descriptive statistic that, in a single number, summarizes and de- scribes the important characteristics of a relationship. The correlation coefficient quan- tifies the pattern in a relationship, examining all X–Y pairs at once. Thus, the correlation coefficient is important because it simplifies a complex relationship involving many scores into one, easily interpreted statistic. Therefore, in any research where a relationship is found, always calculate the appropriate correlation coefficient. As a starting point, the correlation coefficients discussed in this chapter are most commonly associated with correlational research. The term correlation is synonymous with relationship, so in a correlational design we examine the rela- tionship between variables. Often we use a questionnaire or observe participants, but we may also measure scores using any of the methods used in experiments. Recall that correlational studies differ from experiments in terms of how we demonstrate the relationship. For example, say that we hypothesize that as people drink more coffee they become more nervous. To demonstrate this in an experiment, we might assign some people to a condition in which they drink 1 cup of coffee, as- sign others to a 2-cup condition and assign still others to a 3-cup condition. Then we would measure participants’ nervousness and see if more nervousness is related to more coffee. Notice that, by creating the conditions, we (the researchers) determine each participant’s X score because we decide whether their “score” will be 1, 2, or 3 cups on the coffee variable. In a correlational design, however, we do not manipulate any variables, so we do not determine participants’ X scores. Rather, the scores on both variables reflect an amount Understanding Correlational Research 137 or category of a variable that a participant has already experienced. Therefore, we simply measure the two variables and describe the relationship that is present. Thus, we might ask participants the amount of coffee they have consumed today and measure how nervous they are. Recognize that computing a correlation coefficient does not create a correlational design: It is the absence of manipulation that creates the design. In fact, in later chapters we will compute correlation coefficients in experiments. However, correlation coeffi- cients are most often used as the primary descriptive statistic in correlational research, and you must be careful when interpreting the results of such a design. Drawing Conclusions from Correlational Research People often mistakenly think that a correlation automatically indicates causality. How- ever, recall from Chapter 2 that the existence of a relationship does not necessarily indicate that changes in X cause the changes in Y. A relationship—a correlation—can exist, even though one variable does not cause or influence the other. However, in correlational research, we do not always know which factor occurred first. For example, if we simply measure the coffee drink- ing and nervousness of some people after the fact, it may be that participants who were already more nervous then tended to drink more coffee. Therefore, maybe greater nerv- ousness actually caused greater coffee consumption. But, in correlational research, we do little to control or eliminate other potentially causal variables. For exam- ple, in the coffee study, some participants may have had less sleep than others the night before testing. Perhaps the lack of sleep caused those people to be more nervous and to drink more coffee. In experiments we apply the in- dependent variable first, and we control other potential causal variables, so experiments provide better evidence for identifying the causes of a behavior. Unfortunately, this issue is often lost in the popular media, so be skeptical the next time some one uses correlation and cause together. The problem is that people often ignore that a relationship may be a meaningless coincidence. For example, here’s a re- lationship: As the number of toilets in a neighborhood increases, the number of crimes committed in that neighborhood also increases. Crime tends to occur more frequently in the crowded neighborhoods of large cities. Here’s a serious example: A particular neurological disease occurs more often in the colder, northern areas of the United States than in the warmer, southern areas. But, for all the reasons given above, the mere ex- istence of this relationship is not evidence of causality. The north also has fewer sunny days, burns more heating oil, and differs from the south in many other ways. One of these variables might be the cause, while coincidentally, colder temperatures are also present. Instead, correlational research is used to simply describe how nature relates the variables, without identifying the cause. Distinguishing Characteristics of Correlational Analysis There are four major differences between how we handle data in a correlational analy- sis versus in an experiment. First, back in our coffee experiment, we would examine the mean nervousness score (Y) for each condition of the amount of coffee consumed (X). With correlational data, however, we typically have a large range of different X scores: People would probably report many amounts of coffee beyond only 1, 2, or 3 cups. Therefore, in correlational procedures, we do not compute a mean Y score at each X. A second difference is that, because we examine all pairs of X–Y scores, correla- tional procedures involve one sample: In correlational designs, N always stands for the number of pairs of scores in the data. Third, we will not use the terms independent and dependent variable with a correla- tional study (although some researchers argue that these terms are acceptable here). Conversely, if we ask, “For a given nervousness score, what is the amount of coffee consumed? Further, recall that, in a relationship, particular Y scores naturally occur at a particular X.

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Ultimately you want to make sense of data purchase acticin 30gm with mastercard acne facials, and to do that buy acticin 30gm low price skin care jogja, you must compute the appropriate statistic and then correctly interpret it discount acticin 30gm visa acne and hormones. More than anything else generic 30 gm acticin with amex acne quick treatment, you need to learn when and why to use each pro- cedure and how to interpret its answer. At first glance, you might think that this book was written before the invention of computers. However, we focus on using formulas to compute answers “by hand” because that is the only way for you to understand statistics. The instructions in Appendix B are appropriate for version 17, and where needed, different instructions are provided so they are appropriate for earlier versions also. Even if your instructor cannot include this program in your statistics course, eventually you will want to learn it or one like it. Then you can compute the statistics discussed in this book quickly and accurately. You do not speak the language yet, so you must translate the terminology and symbols into things that you understand, and that takes time and effort. Instead, work on statistics a little every day, digesting the material in bite-sized pieces. Concepts build upon one another, and material in one chapter sets up a concept in a later chapter so that things are bite sized for you. At the end of a chapter, use the “Chapter Summary” and “Key Terms” to improve your knowledge of the terminology. You’ll find this information at the begin- ning of chapters in the section “Why Is It Important to Know About. Master the formulas at each step because they often reappear later as part of more complicated formulas. The “Review Questions” are for practicing the terminology, definitions and concepts presented in the chapter. The “Application Questions” give you practice computing and interpreting the answers from each procedure. Therefore, starting in Chapter 3, you’ll see “Integration Questions,” which help you to combine the information from different chapters. Remember, your task is to build a complete mental list of all of the different procedures in this book. Eventually you’ll be in faced with picking the one procedure that’s appropriate for a study from all those we’ve discussed. Make a serious attempt at solving the problem first and only then look at the answer. As you’ll see, there are accepted systems for statistical notation, for rounding an answer, for transforming scores, and for creating graphs. Basic Statistical Notation Statistical notation refers to the standardized code for symbolizing the mathematical operations performed in the formulas and for symbolizing the answers we obtain. Review of Mathematics Used in Statistics 5 Identifying Mathematical Operations We write formulas in statistical notation so that we can apply them to any data. We usually use the symbol X or Y to stand for each individual score obtained in a study. When a formula says to do something to X, it means to do it to all the scores you are calling X. When a formula says to do something to Y, it means to do it to all the scores called X. Addition is indicated by the plus sign, and subtraction is indicated by the minus sign. With subtraction, pay attention to what is subtracted from what and whether the answer is positive or negative. The number above the di- viding line is called the numerator, and the number below the line is called the denomi- nator. Always express fractions as decimals, dividing the denominator into the numerator. Parentheses mean “the quantity,” so always find the quantity inside the parentheses first and then perform the operations outside of the parentheses on that quantity. A square root sign also operates on “the quantity,” so always compute the quantity inside the square root sign first. Thus, 22 1 7 means find the square root of the quan- tity 2 7; so 22 1 7 becomes 29, which is 3. Pay attention to how far the dividing line is drawn because the length of a dividing line determines the quantity that is in the numerator and the denominator. For example, you might see a formula that looks like this: 6 1 14 3 2 1 14 16 16 5 5 5 5 2 264 264 264 8 The longest dividing line means you should divide the square root of 64 into the quan- tity in the numerator. The dividing line in the fraction in the numerator is under only the 6, so first divide 6 by 3, which is 2. If you become confused in reading a formula, remember that there is an order of prece- dence of mathematical operations. Working with Formulas We use a formula to find an answer, and we have sym- bols that stand for that answer. In working any formula, the first step is to copy the formula and then rewrite it, replacing the symbols with their known values. Above, multiplication takes precedence over addition, so multiply and then rewrite the formula as B 5 44 1 3 After adding, B 5 47 For simple procedures, you may have an urge to skip rewriting the formula after each step. Rounding Numbers Close counts in statistics, so you must carry out calculations to the appropriate num- ber of decimal places. The rule is this: Always carry out calculations so that your final answer after rounding has two more decimal places than the original scores. However, do not round off at each intermediate step in a formula; round off only at the end! Thus, if the final answer is to contain two decimal places, round off your intermediate answers to at least three decimal places. Then after you’ve completed all calculations, round off the final answer to two decimal places. To round off a calculation use the following rules: If the number in the next decimal place is 5 or greater, round up. If the number in the next decimal place is less than 5, round down: an answer of 3. We add zeroes to the right of the decimal point to indicate the level of precision we are using. Transforming Scores Many statistical procedures are nothing more than elaborate transformations. A transformation is a mathematical procedure for systematically converting a set of Review of Mathematics Used in Statistics 7 scores into a different set of scores. Adding 5 to each score is a transformation, or converting “number correct” into “percent correct” is a transformation.

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Increasingly buy acticin 30 gm line acne face wash, a single specimen for serology can be obtained and compared to established population values cheap 30gm acticin with amex skin care lab. Therapy is not indicated as it does not substantially alter the course of disease except in the catarrhal phase generic acticin 30 gm without prescription acne no more. Other common causes of chronic cough in- clude asthma buy 30 gm acticin mastercard acne treatment for teens, allergic rhinitis with postnasal drip, and gastroesophageal reflux disease. In these patients, a methacholine challenge test is used to confirm the diagnosis, especially in the setting of normal spirome- try. Peak expiratory flow monitoring in the workplace is useful when an occupational cause of asthma or chronic cough is suggested. Typical clinical features include symptoms that increase over the work week and wane significantly during time off work. Individuals with allergic rhinitis often develop cough as a result of postnasal drip, which can become more severe after upper respiratory illnesses. However, the severity of the cough without prior history of chronic rhinitis in this case argues against allergic rhinitis. Finally, gastroesophageal reflux disease may also be asso- ciated with chronic cough and would be diagnosed with a 24-h pH probe. The preceding illness and abrupt onset of severe symptoms, however, are inconsistent with this diagnosis. This finding suggests that there is an exposure during the week that may be triggering the patient’s asthma. Skin testing for allergies would not be likely to pinpoint the work-related exposure. The patient does not require further testing to diagnose that he has asthma; therefore, a methacholine challenge is not indicated. Finally, the exercise physiol- ogy test is generally used to differentiate between cardiac and pulmonary causes or de- conditioning as etiologies for shortness of breath. Limited sleep studies that measure one or two parameters may be cost-effective when interpreted by experts; however, their predictive capacity does not compare favor- ably to a polysomnogram. Unfortunately there are at present no satisfactory pharmaco- logic options for patients with obstructive sleep apnea. Another treat- ment option is the mandibular repositioning splint, which holds the tongue and lower jaw forward in order to widen the pharyngeal airway. There are several surgical options for patients with narrowed airways that are effective in carefully selected patients. Hypersensitivity pneumonitis is a delayed-type hypersensitivity reaction that has a variety of presentations. Some people develop acute onset of shortness of breath, fevers, chills, and dyspnea within 6 to 8 h of antigen exposure. Others may present subacutely with worsening dyspnea on exertion and dry cough over weeks to months. Chronic hy- persensitivity pneumonitis presents with more severe and persistent symptoms with clubbing. Progressive worsening is common with the development of chronic hypox- emia, pulmonary hypertension, and respiratory failure. Peripheral eosinophilia is not a feature of this disease, although neutrophilia and lymphopenia are frequently present. Other nonspecific markers of inflammation may be elevated, including the erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and serum immunoglobulins. If a specific antigen is suspected, serum precipitins directed toward that antigen may be demonstrated. Histopathologically, interstitial alveolar infiltrates predominate, with a variety of lymphocytes, plasma cells, and occasional eosinophils and neutrophils seen. In patients with mild disease, removal from antigen exposure alone may be sufficient to treat the disease. More severe symptoms require therapy with glucocorti- coids at an equivalent prednisone dose of 1 mg/kg daily for 7 to 14 days. Bronchiectasis results from inflammation and destruction of the bronchial wall and is usually triggered by in- fection. Adeno- virus and influenza virus are the main viruses that can cause bronchiectasis. Patients with im- paired immunity to pulmonary infections, such as those with cystic fibrosis or ciliary dysfunction, are highly susceptible to bronchiectasis. Physical examination findings can be varied and are not sufficient alone for diagnosis. Rhonchi and wheezes can be heard over the affected area; severe cases may present with right-heart failure. If focal, it is most likely due to prior necrotizing infection; however, mycobacterial infection (M. Other possible manifestations include pulmonary hemorrhage, dia- phragmatic dysfunction with loss of lung volumes (the so-called shrinking lung syn- drome), pulmonary vascular disease, acute interstitial pneumonitis, and bronchiolitis obliterans organizing pneumonia. The anaerobes involved are most likely oral, but Bacteroides fragilis is isolated in up to 10% of cases. Vancomycin, ciprofloxacin, and ceph- alexin have no significant activity against anaerobes. For many years penicillin was considered the standard treatment for anaerobic lung infections. However, clinical studies have demonstrated the superiority of clindamycin over penicillin in the treatment of lung abscess. When there are contraindications to clindamycin, penicillin plus metronidazole is likely to be as ef- fective as clindamycin. A viscous, infected pleural fluid can become organized following pneumonia, resulting in development of empyema or chronic pleural effusion with trapped lung that is unable to reexpand. In order to prevent these complications, it is recommended that all pleural effusions separated from the chest wall by >10 mm undergo thoracentesis. Char- acteristics that predict increased likelihood of complications with a parapneumonic effu- sion include: loculated pleural fluid, pleural fluid pH <7. Individuals whose pleural fluid has any of these characteris- tics should be considered for tube thoracostomy drainage of the pleural fluid. The leading causes of death in the early posttransplant period are infectious complications. Primary graft failure oc- curs immediately after the transplant and is sometimes called ischemia-reperfusion injury. Acute rejection occurs in ~50% of lung transplant patients within the first year but is rarely fatal. Posttransplant lymphoproliferative disorder is a B cell lymphoma associated with the Epstein-Barr virus and is related to the degree of immunosuppression. Bronchiolitis obliterans syn- drome denotes chronic rejection and is the leading cause of late mortality in lung transplant. The most common anatomic sites of aspiration (when people are lying on their back) and therefore lung abscess include the superior segment of the right lower lobe, posterior segment of the right upper lobe, and superior segment of the left lower lobe. Anaerobic bacteria are the most prevalent isolates from lung abscesses, as these are the most common bacteria aspirated from the mouth.

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